The latest strip (Failure To Communicate) does nothing for me. That is to say, I was caught up in Skull's predicament until the punchline, which let me right go again.
What possible mis-comprehension could be going through Brent's mind so that he interprets Skull's line, "I mean I really have to go now. Forever." as a plea to go potty? Skull's well-drawn, Cintiq-supported fourth panel is totally un-ambiguous.
No one has to pee forever; Brent's line is pretty lame.